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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. A polygenic burden of rare disruptive mutations in schizophrenia. Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment. Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking.

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For mild-to-moderate cases, it is appropriate to treat for an IBD flare alone if there are no specific additional risk factors for C. In patients with severe colitis, however, particularly in the presence of additional risk factors (e.recent health-care contact, antibiotic use, hospitalization) concomitant treatment for presumed C.